Glutamate Antagonist

Glutamate Antagonist

There is a single glutamate antagonist that can be prescribed to treat Parkinson’s symptoms. It’s not used very often and is most likely to be given along with other Parkinson’s drug treatments. It’s exact mechanisms are not known. It may modify levels of certain chemicals in the brain.

Generic drug names and brand names

• Amantadine (Symmetrel)

Side effects

The listed potential side effects for Amantadine are:

More Common

  • Agitation, anxiety, or nervousness
  • Difficulty concentrating
  • Headache
  • Irritability
  • Loss of appetite
  • Nausea
  • Purplish red, net-like, or blotchy spots on the skin
  • Trouble in sleeping or nightmares

Less common

  • Blurred vision
  • Confusion
  • Difficult urination
  • Dizziness or light-headedness
  • Fainting
  • Seeing, hearing, or feeling things that are not there
  • Swelling of the hands, feet, or lower legs


  • Convulsions (seizures)
  • Decreased vision or any change in vision
  • Difficulty in coordination
  • Fever, chills, or sore throat
  • Increased blood pressure
  • Increase in body movements
  • Irritation and swelling of the eye
  • Loss of memory
  • Mental depression
  • Severe mood or mental changes
  • Skin rash
  • Slurred speech
  • Thoughts of suicide or attempts at suicide
  • Unexplained shortness of breath

For more information

The Parkinson’s UK website is very helpful – click here