Anticholinergics – for resting tremor rather than stiffness

Anticholinergic medications block the action of acetylcholine, a chemical messenger that helps to send messages from your nerves to your muscles.
They are used more for the treatment of resting tremor than stiffness and slowness of movement. Anticholinergics are usually reserved for the treatment of tremor that is not adequately controlled with dopaminergic medications.

Generic drug names and brands

  • Orphenadrine (Biorphen, Disipal)
  • Procyclidine (Arpicolin, Kemadrin)
  • Trihexyphenidyl (Broflex)


Side effects

The NHS website for Orphenadrin states the following potential side effects:


  • Dry mouth
  • Eye or eyesight problems
  • Feeling dizzy
  • Gastrointestinal problems


  • Confusion
  • Convulsions
  • Difficulty sleeping
  • Euphoria
  • Faster heart rate
  • Feeling nervous
  • Hallucinations
  • Hypersensitivity reactions
  • Sedation
  • Urinary retention

For more information

The Parkinson’s UK website has excellent information on anticholinergics click here